Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

ABDOMINAL IMAGING
Year
: 2016  |  Volume : 26  |  Issue : 4  |  Page : 423--428

Abdominal lymphatic malformation: Spectrum of imaging findings


Anupam Lal1, Pankaj Gupta1, Manphool Singhal1, Saroj K Sinha2, Sadhana Lal2, Surinder Rana2, Niranjan Khandelwal1,  
1 Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
2 Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Correspondence Address:
Anupam Lal
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh - 160 012
India

Abstract

Lymphatic malformations are congenital vascular malformations with lymphatic differentiation. Although the most common locations for lymphatic malformation are the neck and axilla, they can occur at several locations in the body including the abdomen. The abdominal location is rather rare and accounts for approximately 5% of all lymphatic malformation. Abdominal lymphatic malformation can arise from mesentery, omentum, gastrointestinal tract, and retroperitoneum. Clinical presentation includes an abdominal lump, vague abdominal discomfort, and secondary complications including intestinal obstruction, volvulus, ischemia, and bleeding. There is a broad spectrum of radiological manifestation. In the present review, we discuss the imaging appearance of abdominal lymphatic malformation. The diagnosis of lymphatic malformation in our series was based on the histopathological examination (in cases who underwent surgery) and fine needle aspiration cytology.



How to cite this article:
Lal A, Gupta P, Singhal M, Sinha SK, Lal S, Rana S, Khandelwal N. Abdominal lymphatic malformation: Spectrum of imaging findings.Indian J Radiol Imaging 2016;26:423-428


How to cite this URL:
Lal A, Gupta P, Singhal M, Sinha SK, Lal S, Rana S, Khandelwal N. Abdominal lymphatic malformation: Spectrum of imaging findings. Indian J Radiol Imaging [serial online] 2016 [cited 2017 Feb 21 ];26:423-428
Available from: http://www.ijri.org/text.asp?2016/26/4/423/195777


Full Text

 Introduction



Lymphatic malformations are a form of congenital vascular malformations. The usual location is head and neck. Abdominal lymphatic malformation are rare, comprising only 5% of all lymphatic malformations. Within the abdominal cavity, they occur in mesentry, retroperitoneum, solid organs (liver, spleen, pancreas) and gastrointestinal tract. Complications including gastrointestinal obstruction, hemorrhage and volvulus mandate treatment in all cases. Surgery remains the treatment of choice. The less invasive form of treatment including per cutaneous sclerotherapy have a greater recurrence rate. In this review we present the imaging spectrum of abdominal lymphatic malformations.

 Embryological Basis



The lymphatic system of the body is derived between 12th and 16th weeks of gestation from endothelial channels located in the neck, root of the mesentery, and the femoral and sciatic vein bifurcation.[1] Sequestration of the lymphatic channels leads to the development of lymphatic malformations. Continued growth of these lesions represents both the accumulation of fluid and the proliferation of pre-existing spaces.

Histopathological appearance

Grossly, lymphatic malformations appear as thin-walled cystic lesions with a smooth external surface. Cut surface may reveal macroscopic or microscopic cysts.[2] The fluid in the cysts may be serous, hemorrhagic, or chylous.[3] Microscopically, the cysts are lined by flattened endothelial cells. The cyst fluid is eosinophilic. The stroma shows collagen fibres, lymphocytes, and occasional lymphoid aggregates.[2]

Clinical features

Both male and female predominance has been reported in abdominal lymphatic malformation. The majority of abdominal lymphatic malformations are diagnosed in children. The clinical presentation is highly variable depending on the size and exact location of the lesion.[1] They are symptomatic in as many as 88%.[2] Presenting features are abdominal pain, abdominal distension, nausea, vomiting, constipation, diarrhea, and abdominal mass.

Specific sites

Mesenteric lymphatic malformation

The mesentery is the most common site for abdominal lymphatic malformations.[3] Mesenteric lymphatic malformations are known to produce serious complications including hemorrhage, intestinal ischemia, obstruction, and volvulus.[4] On ultrasound, lymphatic malformations appear as multilocular cystic masses [Figure 1]A. They are often anechoic but may also contain echogenic debris. Less commonly, the lesions may appear as predominantly solid [Figure 1]B.[5] On computed tomography, the fluid component of the lymphatic malformation is homogeneous and shows low attenuation values [Figure 2]A. Following administration of intravenous contrast, enhancement of the cyst wall and septa is seen [Figure 2]B.[5] Less common computed tomography (CT) manifestation includes negative attenuation values due to the presence of predominantly chylous fluid.[4] Calcification and hemorrhage are other uncommon imaging findings on CT [Figure 2]C.[6],[7],[8] Magnetic resonance imaging (MRI) signal intensity parallels that of the fluid appearing hypointense on T1-weighted images and markedly hyperintense on T2-weighted images [Figrue 3]A. Heterogeneous signal intensity is seen in the presence of hemorrhage and infection [Figure 3]B. In addition to suggesting a diagnosis of lymphatic malformation, imaging provides information regardingthe extent of lesions, aiding in accurate surgical planning.[9]{Figure 1}{Figure 2}{Figure 3}

Percutaneous biopsy is not recommended in typical cases as there is low cellularity and negative yield in most cases. In addition, in rare cases of cystic malignancy, there is a theoretical risk of needle tract seeding. Fine needle aspiration cytology (FNAC) is a less invasive technique compared to biopsy. It allows confident diagnosis of lymphatic malformation, especially in patients with atypical presentation, age, and location. It is a safe alternative to more cumbersome and time-consuming surgical modalities of diagnosis.[10] The differential diagnoses of mesenteric lymphatic malformations include uncomplicated ascites (free of septations) and fluid-containing masses in the abdomen [Figure 4].[4],[11] Ascites is characterized by the lack of septations or displacement of bowel loops. Moreover, ascitic fluid tends to gravitate to the dependent sites including paracolic gutters, Morison's pouch, and pelvis. Mesothelial cysts, enteric duplication cysts, and pseudocysts mimic mesenteric lymphatic malformations closely, and preoperative imaging diagnosis may be impossible. Several other conditions simulating mesenteric lymphatic malformations have been described. These include malignant gynecological lesions (ovarian malignancies) and abdominal tuberculosis. Overall, the features that support lymphatic malformation on imaging include the absence of solid areas, fine septa, low-level septal vascularity, and absence of significant mass effect on adjacent structures. MRI and ultrasound are better at discriminating the cystic nature of the lesions. The role of chemical shift MRI to differentiate mesenteric lymphatic malformations from other cystic masses has also been described.[12] As described above, in certain cases with atypical clinical features, FNAC may aid in diagnosis.{Figure 4}

Retroperitoneal lymphatic malformations

Retroperitoneal lymphatic malformations are extremely rare and comprise less than 1% of the abdominal lymphatic malformations.[13],[14] They usually present in older children and adults. Clinically, they present as palpable abdominal masses, abdominal pain, intestinal or ureteric obstruction, and hematuria. Asymptomatic lesions may be detected incidentally during imaging evaluation for unrelated indications. Histologically, the retroperitoneal lesions are almost always of cystic variety.[1] The imaging features are similar to those of cystic mesenteric lymphatic malformations [Figure 5]A and [Figure 5]B. An important feature on imaging that differentiates these lesions from other pathologies is the insinuating nature crossing multiple compartments. Retroperitoneal cystic teratoma is an important differential diagnosis.[1]{Figure 5}

Gastrointestinal tract lymphatic malformations

Gastrointestinal tract (GIT) is an infrequent location for abdominal lymphatic malformations.[15] These intramural lesions are frequently asymptomatic and detected incidentally on radiologic studies or at endoscopy.[15] The lesions appear as smoothly marginated intramural masses on barium studies and deform with compression. Homogeneous low-attenuation is seen at CT [Figure 6]A and [Figure 6]B. Endoscopic ultrasound confirms the cystic nature of these lesions.{Figure 6}

Hepatic lymphatic malformations

Primary hepatic lymphatic malformations are extremely uncommon. Hepatic lymphatic malformations may be seen in isolation or as a part of systemic lymphatic malformation or hepatosplenic lymphatic malformation.[16] Isolated hepatic lesions are seen in relatively older children and adults compared to systemic or hepatosplenic lymphatic malformation that usually present during infancy, or early childhood. Hepatic lymphatic malformations present as single or multiple cysts [Figure 7]. The imaging features are similar to lymphatic malformations elsewhere in the body. Hyperechoic lesions resembling hemangiomas are also seen infrequently.[5] This appearance is related to small size lymphatic spaces separated by abundant fibrous tissue. The differential diagnosis includes other hepatic cysts including polycystic liver disease, hydatid cysts, and cystic tumors including cystic metastasis and mesenchymal hamartoma.[5]{Figure 7}

Splenic lymphatic malformations

Splenic lymphatic malformations usually occur in subcapsular locations [Figure 8]A. This location reflects the anatomic distribution of lymphatics draining splenic parenchyma. Less common sites for splenic lymphatic malformations include intraparenchymal location presenting as well defined lesions [Figure 8]B or global splenic enlargement.[17] There are no distinct imaging features of splenic lymphatic malformations. Lesions closely resembling splenic lymphatic malformations include true splenic cysts, pseudocysts, infective lesions including pyogenic abscesses and hydatidcysts, infarction, peliosis, and neoplastic lesions including hemangioma, lymphoma, and cystic metastasis.[17]{Figure 8}

Lymphatic malformations of extrahepatic biliary tree

This is a rare site for abdominal lymphatic malformations. These lesions usually arise from the gallbladder and are characterized by multilocular cystic appearance compressing the gallbladder lumen.[18]

Renal lymphatic malformations

Renal lymphatic malformations are rare lesions and usually present as focal lesions [Figure 9]A, [Figure 9]B, [Figure 9]C, [Figure 9]D.[19] Less commonly, these present as diffuse lymphatic malformations or renal lymphangectasia[Figure 10]. They appear as cystic lesions (uni or multilocular) on imaging. Rare cases of solid appearing lymphatic malformations have been reported.[7] The proposed mechanism for such appearance is the numerous interfaces between microcysts of the lymphatic malformation. Differential diagnosis on imaging in adults includes hydronephrosis, benign renal cysts, renal abscess, and cystic renal tumors including multilocular cystic nephroma and renal cell carcinoma. Multilocular cystic nephroma is the chief differential diagnosis in children.{Figure 9}{Figure 10}

Pancreatic lymphatic malformations

Lymphatic malformations are said to be of primary pancreatic origin only when they are located within the pancreatic parenchyma, are attached to the pancreas by a pedicle, or have a broad area of contact with the pancreas [Figure 11].[20] The most common cystic lesion in relation to the pancreas is a pseudocyst. Other differential considerations are cystic neoplasms including cystic neuroendocrine neoplasms, mucinous or serous neoplasms, solid pseudopapillary epithelial neoplasms, and intraductal papillary mucinous neoplasms. Definite imaging diagnosis is difficult as these lesions closely resemble lymphatic malformations.{Figure 11}

 Treatment



Treatment is recommended in all (even asymptomatic) cases as the incidence of several complications such as bleeding, infection, bowel obstruction, and volvulus tends to increase with time as the lesion size increases.[21],[22] Complete resection has conventionally been advocated as the treatment of choice for all types of abdominal lymphatic malformations. For all sites combined, a recurrence rate of 40% after incomplete resection and 17% after macroscopically complete resection was shown. Moreover, recurrence is more common in larger lesions.[23] Sclerotherapy is the less invasive form of treatment. A variety of sclerosing agents, including ethanol, sodium tetradecylsulfate, bleomycin, doxycycline, and OK-432 (picibanil), has been shown to be effective in the treatment of macrocystic lesions.[21] Variable recurrence has been reported following sclerotherapy, with up to 100% in some series.[24],[25] The rate of recurrence depends on the lesion location, size, and complexity.[26],[27]

 Conclusion



Abdominal lymphatic malformations, although rare, should be kept in the differential diagnosis of cystic lesions occurring in the various abdominal compartment and abdominal viscera, both solid and GIT. Clinical presentation is extremely variable. Preoperative diagnosis may be facilitated by FNAC. Definite treatment is required in most cases due to the fear of complications. Surgery is the mainstay of treatment. Other forms of treatment may have a higher recurrence rate.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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